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A six-case series of digital epipen injection injuries, a review of the literature and treatment protocols with their pathophysiological and pharmacological basis are presented.
Methods: we searched the literature for all studies of epinephrine in sealed syringes, vials, or ampules in concentrations between 1:1,000 and 1:10,000, that measured epinephrine in samples exposed to temperatures above and/or below the recommended storage temperature compared with control samples.
We therefore conducted a systematic review of the literature searching key databases for high quality published and unpublished material on the use of adrenaline for emergency treatment; in addition, we contacted experts in this area and the relevant pharmaceutical companies.
Adrenaline dose in anaphylactic shock
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To review the lit on pharmacokinetics of epinephrine autoinjectors.
The exclusive trial evidence exposed for the pinch management of anaphylaxis was in relation back to adrenaline, only these trials rich person been undertaken stylish patients who were at the clip not experiencing.
Contraindications of adrenaline
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The studies, all connected healthy volunteers, were completed by simons, edwards, duvauchelle, louse and turner terminated the span of 2 decades.
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Adrenaline in anaphylaxis mechanism of action
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Adrenaline side effects
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In may 2015, letter a systematic literature hunting was performed stylish pubmed, embase, the cochrane library, and crd databases.
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However, the association betwixt outcomes and the time of Adrenalin administration was unknown.
Six studies assessing epinephrin autoinjector pharmacokinetics were identified.
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Adventitious digital adrenaline autoinjection is an especial injury, with exclusive a few case reports existing stylish the literature.
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The timing of epinephrine administration plays A key role fashionable cardiac arrest resuscitation strategies.
This comprehensive brushup of the foreign literature has saved little robust grounds for the pointed or long-term direction of anaphylaxis.
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Pharmacological basis of adrenaline in anaphylactic shock
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This article reviews the current literature connected articaine use stylish dentistry specifically addressing the issues of efficacy and safety.
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Epinephrine
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What are the effects of adrenaline on blood pressure?
A study of 36 adult pigs, which were randomised to one of two adrenaline doses (20 or 30 μg/kg) or to placebo, bolused every 3 minutes, documented increased arterial blood pressure and increased CePP in the adrenaline groups [ 2 ].
How is Adrenaline used in advanced life support?
Adrenaline has been a key component of advanced life support algorithms for many years. Its mechanism of action—stimulation of α 1 receptors in vascular smooth muscle—causes vasoconstriction. This increases the aortic diastolic pressure, which increases coronary perfusion pressure (CPP) and cerebral perfusion pressure (CePP).
What is the rate of survival with adrenaline?
Although the raw outcome data indicate a higher rate of one-month survival in those receiving adrenaline, after propensity matching the aOR for one-month survival was 0.54 (95% CI 0.43–0.68) and for CPC 1–2 the aOR was 0.21 (95% CI 0.10–0.44).
Are there any studies of adrenaline in anaphylactics?
All the studies reported Cmax; however, due to the inconsistency between study cohorts and variation in adrenaline plasma concentrations between studies, it was not possible to pool results for further statistical analysis and inform the dosing of adrenaline in anaphylaxis situation. TABLE 1. Summary of PK studies
Last Update: Oct 2021
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This image illustrates Pharmacological basis of adrenaline in anaphylactic shock.
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